The USAID/Renew SME Gender Growth Acceleration Playbook provides a practical guide for fund managers and ecosystem actors seeking to strengthen the performance and scalability of women-led small and medium-sized enterprises (SMEs). Developed to address structural barriers limiting women entrepreneurs’ access to growth capital, the playbook outlines diagnostic tools, technical assistance strategies, and gender-smart operational approaches that can be integrated across the investment lifecycle. It emphasizes linking capital deployment with targeted capacity building, including mentorship, business advisory support, and market access interventions. The resource highlights how combining financial investment with structured growth support can enhance portfolio performance while advancing women’s economic empowerment. Designed for practitioners, it offers actionable frameworks for embedding gender-responsive strategies within SME investment and acceleration programs.