This practical guide, developed by Chemonics and DAI, examines the various applications of the blended finance structuring approach in the gender-lens investing field. The paper provides commentaries on the different components of transaction design, including issue-framing, stakeholder analysis and overviews of relevant financial instruments. This document aims to provide targeted design considerations and guidelines for how to frame the discussion – including practical advice around potential market opportunities and the respective stakeholders, financing needs and challenges to accessing finance, and relevant innovative financing mechanisms to unlock capital.